Effects of ß-aminoisobutyric acid(BAIBA) on Peripheral Neuropathy after Paclitaxel Treatment

February 28, 2023  |  Vol.9, No.2  |  PP. 193-202  | PDF

AUTHORS:

Jae Sung Park, Physical Education Department, Kongju National University, Republic of Korea

KEYWORDS:

Peripheral Neuropathy, Paclitaxel, Exercise Mimetics, ß-Aminoisobutyric Acid (BAIBA)

Abstract

Peripheral neuropathy is a common side effect resulting from treatment with the cancer chemotherapeutic drug paclitaxel. Paclitaxel binds to beta-tubulin and stabilized its polymerization. This leads to disruption of the mitotic spindle and arrest of the cell division. What we know is that paclitaxel treatment of neurons leads to an increase and altered distribution of detyrosinated tubulin, a marker for stable microtubules. There is growing evidences that exercise decreases symptoms of acute pain in human, has numerous beneficial effects on chronic disease, has an anti-inflammatory effect, and reduces neuropathic pain in rodents. Recent study report that PPAR-a ligands reduced behavioral signs of inflammatory pain in rats which is known to be up regulated by exercise. Also, the exercise mediated neurotrophic factors are believed to play an antinociceptive role. In this study, we used in vitro models of paclitaxel neuropathy to examine the potential neuroprotective effects of exercise. To conduct this experiment, we employed a metabolomic approach to examine metabolites in neuronal cells with chemotherapeutic drug paclitaxel, and medicated ß-aminoisobutyric acid (BAIBA) as exercise mimetics. ß-aminoisobutyric acid (BAIBA), a natural thymine catabolite, is involved in the beneficial effects of exercise on metabolic disorders. In particular, it has been reported to reverse the inflammatory processes observed in the peripheral organs of animal models of obesity. Also we did ATP assay to investigate the toxicity of our Immortalized DRG neuronal cells(50B11). We obtained that treatment of exercise mimetic drug, b-aminoisobutyric acid (BAIBA), has beneficial effect on paclitaxel neuropathy model. Our result suggest that exercise training protect or decreases peripheral neuropathic pain induced by paclitaxel treatment.

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Citations:

APA:
Park, J. S. (2023). Effects of ß-aminoisobutyric acid(BAIBA) on Peripheral Neuropathy after Paclitaxel Treatment. Asia-pacific Journal of Convergent Research Interchange (APJCRI), ISSN: 2508-9080 (Print); 2671-5325 (Online), KCTRS, 9(2), 193-202. doi: 10.47116/apjcri.2023.02.15

MLA:
Park, Jae Sung, “Effects of ß-aminoisobutyric acid(BAIBA) on Peripheral Neuropathy after Paclitaxel Treatment.” Asia-pacific Journal of Convergent Research Interchange, ISSN: 2508-9080 (Print); 2671-5325 (Online), KCTRS, vol. 9, no. 2, 2023, pp. 193-202. APJCRI, http://fucos.or.kr/journal/APJCRI/Articles/v9n2/15.html.

IEEE:
[1] J. S. Park, “Effects of ß-aminoisobutyric acid(BAIBA) on Peripheral Neuropathy after Paclitaxel Treatment.” Asia-pacific Journal of Convergent Research Interchange (APJCRI), ISSN: 2508-9080 (Print); 2671-5325 (Online), KCTRS, vol. 9, no. 2, pp. 193-202, February 2023.

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